ABSTRACT

Objective: The present study was to evaluate the antifertility activity of ethanolic extract of Cordia oblique leaves on female wistar rats. Materials and Methods: Three groups of rats were administered orally (EECOL) ethanolic extract of Cordia obliqua leaves at doses of 200 and 400 mg/kg body weight daily for 10 days. The control group received Tween 80. On day 10 of gestation, preserve for histopathology evaluation of each rat uterus was examined to determine the number of implantation. and body weights is compared to the respective initial body weights, and the blood collected for biochemical evaluation of estrogen. Results: Oral administration of the extract from days 1 to 10 of gestation showed reduction (p<0.05) in the number of live fetuses. Anti-implantation activity of the treatment groups were 61% and 100% for groups II to III respectively, whereas antifertility activity of the groups was found to be 61% and 100% in the same order. Conclusion: The results suggest that ethanolic extract of Cordia oblique leaves could induce positive effects on antifertility activity of female wistar rats. Key words: Antifertility, Cordia obliqua, Anti-implantation
Publication date: 01/06/21

https://ijbpas.com/pdf/2021/June/MS_IJBPAS_2021_5524.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.6.5524