ABSTRACT

This study was conducted to determine thereported the present study is aimed to evaluate the antifertility activity of the effect of Eugenol and Ocimum sanctum Linn. leaf extract on Liver and Serum biochemical alterations. The analysis was carried out the experiments were conducted to investigate the healthy female albino rats were administered with EUG (99% pure) at a dose of 0.4 ml/day/rat and OS Linn. (Tulsi) leaf extract at a dose of 500 mg/kg body weight/day/rat orally for 15 days. One-way ANOVA analysis with Dunnett’s multiple comparison test is used for analyzing data.The biological assay results showed that the Total Lipids were significantly increased in both administrations (P<0.001). The DNA and RNA levels were significantly increased in liver by both administrations (P<0.001). SGOT levels were significantly elevated in serum by Eugenol administration (P<0.001), in OS administration where it was reduced (P<0.001). Consequently, according to our results, the present investigation suggest that the triglycerides were significantly increased in liver by both administrations. Liver cells can synthesize, store triglycerides and into cholesterol. The activity of SGOT, SGPT levels was significantly increased in Serum by OS administration. These we may cause stabilized cell membrane and protect the liver against deleterious agents and free radical-mediated toxic damages to the liver cells. Keywords: Eugenol, Ocimum sanctum, Reddy M* SGOT, SGPT, Cholesterol, HDL, LDL, Liver and serum
Publication date: 01/06/21

https://ijbpas.com/pdf/2021/June/MS_IJBPAS_2021_5519.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.6.5519