ABSTRACT

In the present study, the methanol, Ethylacetate, and hexane extracts of Tinospora sinensis leaves were studied for ?- amylase inhibition using an in vitro model. The plant extracts were also examined for its antioxidant activities by using free radical 1,1-diphenyl-2-picryl hydrazyl (DPPH) scavenging method, radical scavenging ability, reducing power capacity, estimation of total phenolic content, flavonoid content. The study exposed that the different concentrations of the extract possessed a very good amount of total phenolics, flavonoid and exhibit potent radical scavenging activity using DPPH as substrate. The methanol and ethyl acetate extract exhibited significantly ?-amylase inhibitory activities with an IC50 value 202.2 and 327.1 dry extract respectively and well compared with standard acarbose drugs. Thus, it could be concluded that due to the presence of antioxidant components the plant extract have well prospective for the management of hyperglycemia, diabetes and the related condition of oxidative stress. Keywords: Tinospora sincensis, leaves extract, Antioxidant activities, DPPH radical activity and ?-amylase inhibitory activity
Publication date: 01/06/21

https://ijbpas.com/pdf/2021/June/MS_IJBPAS_2021_5507.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.6.5507