ABSTRACT

The design and synthesis of new Gemifloxacin C-7 modified analogues is described here with selected NSAIDs , which were characterized through FT-IR, 1HNMR and Mass spectroscopy having high lipophilic character Log P values (4.58-4.94) in comparison with GMFX (0.80). Most of them have altered antibacterial and antifungal activity, while compound 4a and 3a unveils increased activity against few Gram negatives and Gram positive bacterial strains in comparison with parent molecule (gemifloxacin). These results were further analyzed through one-way ANOVA by using SPSS ver. 20.Compound 1a, 2a, 4a and 5a showed higher enzymatic activity against urease than standard and parent molecule. However, only 5a produced mild inhibitory activity against ?-chymotrypsin. Key words: Gemifloxacin, synthesis, analogues, microbial activities, enzymatic activities
Publication date: 01/06/21

https://ijbpas.com/pdf/2021/June/MS_IJBPAS_2021_5486.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.6.5486