ABSTRACT

Background: To investigate the effect of various extracts of combination of herbal drug on the occurrence of oxidative stress in the organ of rats during diabetes by measuring the extent of oxidative damage as well as the status of the antioxidant defense system. Methods: Various extracts of combination of herbal drug was administered orally and different doses of the extract on superoxide dismutase (SOD), catalase (CAT), glutathione peroxidaase (GPx), glutathione-S-transferase (GST) and reduced glutathione (GSH) were estimated in streptozotocin-induced diabetic rats. Glibenclamide was used as standard reference drug. Results: Significant increase in the activities of plasma insulin, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and vitamin C and E were observed in brain on treatment with 200 mg/kg body weight of combination of herbal extract and glibenclamide for 3 weeks. Conclusions: Since the study of induction of the antioxidant enzymes is considered to be a reliable marker for evaluating the antiperoxidative efficacy of the medicinal plant, these findings are suggestions of possible antiperoxidative role played by combination of herbal extract. Keywords: Streptozotocin, in vivo antioxidant activity, male wistar rats
Publication date: 01/02/21

https://ijbpas.com/pdf/2021/February/MS_IJBPAS_2021_53654.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.2.5365