ABSTRACT

Alginate, a naturally occurring biopolymer derived from brown algae (kelp), has many specific properties that have allowed it to be used as a matrix for the trapping and/or release of a variety of biological agents. Alginate is a linear unbranched polysaccharide family that comprises different amounts of 1,4-linked ?-D-mannuronic acid and ?-L-guluronic acid residues. Alginate is a biomaterial that has found ample applications in drug delivery due to its favorable properties, including thickening, gel forming, stabilizing and biocompatibility properties and biodegradability. In addition, the low price, easy availability, natural origin, versatility and transitional properties of sol-gel make alginate the ideal candidate for producing particles with different applications. The oral route is preferred for drug administration by the most patients. The presence of a mucus layer covering the entire gastrointestinal tract was exploited to extend the use of the oral route by creating a method for the delivery of mucoadhesive drugs that demonstrated extended residence time. Nanoparticles composed of alginate have emerged as one of the most extensively characterized biomaterials used for drug delivery and targeting a set of administration routes. Therefore, the development of synthetic derivatives has the ability to motivate the next generation of alginate applications. This review article gives a comprehensive overview on its present use in various fields of controlled drug delivery, biomedical applications and future possibilities. Keywords: Alginate, Extraction process, Drug delivery and targeting, Cancer, Wound healing, 3D bio printing
Publication date: 01/05/21

https://ijbpas.com/pdf/2021/May/MS_IJBPAS_2021_5467.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.5.5467