ABSTRACT

Present work was designed to investigate the antidiarrhoeal potential of the polyherbal formulation prepared using extract of Aegle marmelos, Punica granatum and Piper nigrum with excipients. Antidiarrhoeal effect was evaluated against castor oil and magnesium sulphate induced diarrhoea model in mice. Antimotility effect was evaluated in charcoal meal test in mice while antisecretory effect was evaluated in castor oil induced intestinal secretions in mice. The studies revealed that at a dose of 8 ml/kg polyherbal formulation showed significant reduction of diarrhoea compared to vehicle control group when subjected to castor oil and magnesium sulphate induced diarrhoea, intestinal motility and castor oil induced intestinal secretions in mice. Polyherbal formulation was found to be the effective antidiarrhoeal remedy as the antidiarrhoeal efficacy of the polyherbal formulation was commensurable to standard drug Loperamide. Keywords: Polyherbal formulation, antidiarrhoeal, antimotility and antisecretory
Publication date: 01/05/21

https://ijbpas.com/pdf/2021/May/MS_IJBPAS_2021_5456.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.5.5456