ABSTRACT

BACKGROUND: Recent advancement in the field of medicine, scientists are able to understand the role of vitamin D and oxidative stress in the development of myocardial infarction. The generation of free radicals has harmful effects on cardiovascular system such as myocardial infarction (MI). The aim of the current study is to evaluate the relationship of vitamin D and oxidative stress in the onset of myocardial infarction. METHODOLOGY: In this case and control study fifty diagnosed cases of MI with the help of ST-changes on ECG and Troponin I levels (Group B) and fifty age and sex matched healthy participants (Group A), as a controls, were selected. Sampling was done from different cardiac institutes of Lahore in the duration of six months from February, 2020 to July, 2020. An informed consent was taken from all participants before sampling. Five milliliters of blood were drawn from cubital vein; serum was stored at -70oC after centrifugation for further analysis. All of them were screened for the oxidative stress markers, anti-oxidants and vitamin D with the help of their respective methods. Independent t- test was used to check the significance of different variable with the help of software SPSS (version 21). Pvalve less than 0.05 remained the significant. RESULTS: Current study shows that levels of oxidative stress markers such as Isoprostanes (IsoP-F2?), Malondialdehyde (MDA), 4-hydroxynonenal (4-HNE) and 8-hydroxydeoxyguanosine (8-OHdG) were significantly elevated in Group B as compared to the Group A. Statistically significant low levels of natural anti-oxidants of human body, Glutathione (GSH), Superoxide dismutase (SOD) and Catalase (CAT), were found. Vitamin D levels of participants also measured and when compared with control group we found sever vitamin D deficiency in Group B. CONCLUSION: From the results of the current study, it can be concluded that increased oxidative stress species (HNE, MDA, IsoP, 8OHG) and deficient anti-oxidants (GSH, CAT, SOD) or vitamin D may contribute as a risk factor in the of myocardial infarction. Keywords: Myocardial Infarction, Oxidative Stress Markers, Risk Factors, Reactive Oxygen Species, Vitamin D
Publication date: 01/04/21

https://ijbpas.com/pdf/2021/April/MS_IJBPAS_2021_5465.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.4.5465