ABSTRACT

OBJECTIVES: The COVID-19 pandemic, caused by novel SARS-CoV-2 virus, has taken millions of lives and still scientists are working day and night to sort out its sequence of pathological events in human body. This involved a super complicated chain of inflammatory and immune response events comprising epithelial cells and endothelium damage. The current study aims to assess the involvement of matrix metalloproteinase (MMPs) and reactive oxygen species (ROS) in the pathogenies of COVID-19 infection and their role as a prognostic mark. METHODOLOGY: The current cross sectional comparative study recruited total of one hundred participants that were further stratified into two groups. Group A consisted of fifty healthy individuals, whereas Group B enrolled fifty diagnosed cases of COVID-19 infection. Written consent was taken from the participants before including them in study. The levels of MMPs (3, 9, 12), ROS and antioxidants were measured by the ELISA kits in nominated laboratories of Hospitals under strict protocols set by the center of control (CDC). Statistical analysis was performed by using SPSS (V-21) and p-valve less than 0.05 considered significant. RESULTS: A significant rise in MMP-3, MMP-9 and MMP-12 levels were found in COVID-19 patients as compared to healthy controls. This was accompanied by elevated levels of oxidative stress marker Malondialdehyde (MDA) and reduced levels of anti-oxidants. CONCLUSION: The elevated levels of MMP-3, MMP-9, MMP-12, MDA and reduced levels of anti-oxidants such as Glutathione (GSH), super oxide dismutase (SOD) and catalase (CAT) encourages scientists for more human targeted researches on the important role of MMPs in the development, progression, treatment and follow-up of COVID-19. Keywords: Anti-oxidants, COVID-19, Catalase, Glutathione, Matrix Metalloproteinase, Malondialdehyde, Super Oxide Dismutase
Publication date: 01/04/21

https://ijbpas.com/pdf/2021/April/MS_IJBPAS_2021_5464.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2021/10.4.5464