ABSTRACT

The study is focused to develop and validate a UV-Spectrophotometric method for estimation of Fluphenazine HCL from bulk and their dosage form. Based on spectrophotometric characteristic of method are described for the determination of Fluphenazine at 256 nm was found adequate for quantification. The method was validated for linearity, accuracy, precision and robustness as per International Conference on Harmonization guidelines. The linearity signal and concentration of Fluphenazine in the range of 2–22 ?g/ml in aqueous solution present a correlation coefficient (r2) of 0.9939 for simple UV spectrum. The limit of detection (LOD) and limit of quantitation (LOQ) were 1.87 and 5.68 ?g/ml, respectively. The method was found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of Fluphenazine bulk and marketed dosage form. Keywords: UV-Spectrophotometric, Fluphenazine HCL, bulk and dosage form
Publication date: 01/04/21

https://ijbpas.com/pdf/2021/April/MS_IJBPAS_2021_5438.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.4.5438