ABSTRACT

Selection of Pharmaceutical excipients based on drug excipient compatibility is a part of preformulation study. The compatibility between etodolac and commonly used pharmaceutical excipients in the formulation of nanoparticles was assessed by using Fourier-transform infrared spectroscopy (FTIR) and Differential scanning colorimeter (DSC). The study was carried out by using drug and its pharmaceutical excipients individually and their physical mixture with ratio of 1:1. Results showed that no interactions between etodolac and pharmaceutical formulation excipients were observed by both Fourier-transform infrared spectroscopy and Differential scanning colorimeter. Drug excipient compatibility study of etodolac loaded nanoparticles confirmed the absence of drug excipient interaction in the Nano formulation. Hence, results of the study concluded that modified release nanoparticles of etodolac can be successfully prepared by using Eutragit RS 100 as coating material. Keywords: Nanoparticles, Etodolac, Fourier-transform infrared spectroscopy and Differential scanning colorimeter
Publication date: 01/04/21

https://ijbpas.com/pdf/2021/April/MS_IJBPAS_2021_5432.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.4.5432