ABSTRACT

The present study was undertaken to investigate the diuretic effect of ethnolic extract of the dried plant of Pedalium murex in normal rats. Ethanolic extract of Pedalium murex plant was administered to experimental rats orally at the doses of 50 and 100 mg/kg p.o. Thiazide (150 ug/kg) was used as positive control in the study. The diuretic effect of the extract was evaluated by measuring urine volume & sodium and potassium content. Urine volume was significantly increased by ethanolic extract in comparison to the control group, while the excretion of sodium was also increased by extract. The ethanolic extract had the additional advantage of a potassiumconserving effect. We can conclude that ethnolic extract of Pedalium murex produced notable diuretic effect which appeared to be comparable to that produced by the reference diuretic thiazide. The present study provides a quantitative basis for explaining the folkloric use of Pedalium murexas a diuretic agent. Keywords: Diuretic activity, Pedalium murex, Thiazide, medicinal plants
Publication date: 1/1/21

https://ijbpas.com/pdf/2021/January/MS_IJBPAS_2021_JAN_SPCL_1020.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.1.1020