ABSTRACT

Diabetes represents a major public health burden, both locally and globally. From 1985 to 2000, the number of people living with diabetes globally rose from 30 million to 171 million. Future projections have estimated the prevalence of diabetes to exceed 300 million cases by 2030, with the majority of growth occurring in developing countries. Free radicals are highly reactive molecules generated by biochemical redox reactions that occur as part of normal cell metabolism and in the course of free radical mediated diseases such as arthritis, renal, cardiovascular, inflammatory, infectious, neurological diseases, diabetes mellitus and cancer. An antioxidant is a molecule capable of slowing (or) preventing the oxidation of other molecules. Early research on the role of anti oxidants in biology of focused on their use in preventing the oxidation of unsaturated fats, which is the cause of rancidity. The production of this aldehyde is used as a biomarker to measure the levels of oxidative stress in an organize. Malondialdehyde mainly exists in the enol form. A substantial portion of the population of the United States has the Metabolic Syndrome, a condition that greatly increases risk for cardiovascular disease and diabetes. Insulin resistance, and the resulting compensatory hyperinsulinemia, is the principal pathophysiologic abnormality underlying the majority of these cases. Different physiological processes associated with various components of the metabolic syndrome contain unique information about diabetes risk. Microalbunuria is more likely to be a complication of the type 2 diabetes or hypertension than amarker of the metabolic syndrome. Moreover, easily applicable testing to diagnose insulin resistance accurately in the general population is currently not feasible. It is therefore necessary to broaden the criteria that define the metabolic syndrome to include other conditions associated with the presence of insulin resistance. Such conditions include the following: a family history of type 2 diabetes or coronary artery disease in first- or second-degree relatives, signs of an over active sympathetic nervous system, and elevated concentrations of uric acid. By recognizing these "other conditions," appropriate lifestyle changes and medication can be recommended to help prevent cardiovascular disease and diabetes from developing in these high risk patients. Keywords: Diabetes Mellitus, Antioxidant, Uric acid, Metabolic Syndrome
Publication date: 1/1/21

https://ijbpas.com/pdf/2021/January/MS_IJBPAS_2021_JAN_SPCL_1012.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.1.1012