ABSTRACT

There are many cell-cycle regulators but Ki-67 remains one of the most important antigen. Immunohistochemistry determines the expression of Ki-67 antigen. In all active phases of the cell cycle, there is a nuclear non-histone protein of 395 KD which is expressed and reacts with the anti- body Ki-67. In several studies Ki-67 is considered a prognostic factor for breast cancer. A high Ki-67 labelling index is associated with poor differentiation of tumors and large tumor size in breast carcinoma, carcinoma of the tongue, which were demonstrated in many studies. Many studies stated that in oral squamous cell carcinoma Ki-67 can be considered a good prognostic marker. Keywords: KI-67, Oral Squamous Cell, Carcinoma, Immunohistochemistry
Publication date: 1/1/21

https://ijbpas.com/pdf/2021/January/MS_IJBPAS_2021_JAN_SPCL_1010.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.1.1010