ABSTRACT

Chronic kidney disease (CKD) is a major condition in which oxidative processes are implicated by the amplification of inflammatory responses. Hemodialysis (HD) represents a state of chronic stress for the patient where the oxidative reactions are mainly due to bio incompatibility of components of dialysis apparatus leading to the production of ROS by inflammatory cells. Lipid peroxidation leads to alterations in the biological membranes and is involved in the progression of renal injury. FRAP is said to give more biologically relevant information than that provided by individual antioxidant measurements and which may describe the dynamic equilibrium between pro-oxidants and antioxidants in the plasma. A significant increase in plasma MDA was found in CKD and Pre HD patients and in Hemodialysis with pre HD Increased levels were found when comparing with post HD (P<0.05), along with significant decrease in the antioxidants like Uric acid and FRAP levels were found in Pre HD comparing with CKD and Pre HD with Post HD (P<0.05). FRAP is being used as a single test to estimate total antioxidant capacity (TAC) of blood. FRAP may be considered as an easy, cost effective method to measure the antioxidant power and it might be incorporated into risk prediction in dialysis and CKD. Keywords: Chronic kidney disease, Hemodialysis, Oxidative stress; Free radicals, Antioxidants
Publication date: 1/1/21

https://ijbpas.com/pdf/2021/January/MS_IJBPAS_2021_JAN_SPCL_1003.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.1.1003