BACKGROUND: Acute myocardial infarction is characterized by a significant hemodynamic
insult leading to epicardial coronary arteries atherosclerosis. As thyroid hormone is important
regulator of the cardiac gene expression, many of the cardiac expressions of thyroid dysfunction
are linked with the alterations in the T3-mediated gene expression that changes in the cardiac
contractility, cardiac output, vascular resistance, rhythm disturbances and blood pressure.
METHODOLOGY: We have selected fifty AMI patients from Gulab Devi Chest Hospital,
Lahore to evaluate thyroid biomarkers, oxidative stress and lipid peroxidation markers from their
blood samples. Variables include antioxidant (CAT, SOD, GPX, GRx, GSH, Vitamins (A, C, E,
B6, B9, B12), stress markers (NO, AOPPs, MDA), and thyroid biomarkers (T3, T4, TSH,
TPOAb, TgAb) are determined by different lab tests and ELISA kits. Independent t-test was
applied for analysis.
RESULTS: The mean MDA level in AMI patients was 2.16 ± 0.0015?mol/L while in control
group was 0.951±0.001?mol/L. Nitric oxide in diseased patients 35.26±3.26?mol/L is
remarkably increased as compared to normal subjects’ 23.26±4.26?mol/L. The AOPPs shows significant increased levels in AMI group 127.06±7.26?mol/L in comparison with normal
subjects 99.26±4.23?mol/L. AMI disease patients shows a decreased level of T3 3.05±0.16?g/dl,
T4 16.35±4.26pmol/L, TSH 5.26±2.16IU/L, TPO9.66±2.66 IU/L and TBG 51.26±4.41 IU/L as
compared to healthy controls. The mean SOD (0.36±0.0016U/ml vs. 0.625±.0011U/ml), CAT
serum levels in AMI group were 2.16±0.47 U/L, whereas in the control group was 4.26±0.016
U/L. The mean serum level of GSH and GRx, and GPx in acute myocardial infarct disease
patient was recorded as 6.23±1.99 ?mol/L, 3.08±0.06 ?mol/L and 7.23±1.66 ?mol/L
respectively. Levels of IL-6 and TNF-? in blood serum of AMI patients reported 6.28±1.23pg/ml
and 37.09±2.09pg/ml respectively. Vitamin A, C, E, B6, B9, and vitamin B12 in blood serum of
AMI group are 4.26±1.08nmol/L, 0.415±0.014nmol/L, 0.326±0.0014nmol/L, 66.35±4.29nmol/L,
2.16±0.016nmol/L, and 201.11±6.35pmol/L respectively compared to healthy controls group.
CONCLUSION: The present work signifies that dysfunction of thyroid along with the oxidative
stress and decreased antioxidant capacity might be associated with the progression of acute
myocardial infarction by induction of endothelial dysfunction followed by atherosclerosis.
Keywords: Acute myocardial infarction, Thyroid Hormones, Oxidative Stress, Lipid
Peroxidation, antioxidants, vitamins
Publication date: 01/03/21
https://ijbpas.com/pdf/2021/March/MS_IJBPAS_2021_5421.pdf
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https://doi.org/10.31032/IJBPAS/2021/10.3.5421
