ABSTRACT

Hyperthyroidism is a common endocrine disorder, the complications of untreated disease include hypertension, osteoporosis and cardiovascular system. There are many anti - thyroid drugs but the main shortcoming is that the hyperthyroidism often comes back after they are discontinued. That’s why it still needs attention for more effective treatments. The aim of the present work was to present an outline of the structural and functional aspects of protein responsible for hyperthyroidism from Homo sapiens. First, the genes responsible for hyperthyroidism were identified and investigated through different computational tools and servers to exploit its functional analysis, phylogenetic assessment, 3D structural modelling and quality analysis of the generated 3D model. The 3D structure of all the selected proteins those structures were not present in PDB database, were generated. Further, protein-protein interaction analysis was also performed to observe the functional involvement of these proteins in metabolic pathway. The docking study was performed against all proteins which were having maximum involvement in metabolic pathways. Thus, the present work may facilitate in-vitro and in-vivo studies to design novel and potential inhibitors against hyperthyroidism. Keywords: Endocrine disorder, metabolic pathway, phylogenetic analysis, 3D structural modelling
Publication date: 01/03/21

https://ijbpas.com/pdf/2021/March/MS_IJBPAS_2021_5405.pdf

Download PDF
Download SUPPLEMENTARY Download SUPPLEMENTARY https://doi.org/10.31032/IJBPAS/2021/10.3.5405