ABSTRACT

Many of the newly discovered moieties of chemical drugs are poorly soluble in water. Similarly, the classification of BCS, Class II, and IV medicines is considered to be poorly soluble in water. Hence the enhancement of oral absorption and the bioavailability of solid dosage types remains a concern to formulate scientists based on their criteria for solubility. Consequently, several techniques are being investigated to improve its solubility. One of the most powerful ways to improve solubility is strong dispersion. Solid dispersions have drawn significant interest in increasing the rate of dissolution and thus the bioavailability of a variety of hydrophobic drugs as an efficient means. Similar to conventional formulations like tablets or capsules, there are many benefits of solid dispersions that can be formulated using different methods. In this review article, we discuss some modern and innovative Solid Dispersion strategies to boost the bioavailability of several poorly soluble drugs. Keywords: Solid Dispersions, Dissolution, Bioavailability
Publication date: 01/03/21

https://ijbpas.com/pdf/2021/March/MS_IJBPAS_2021_5397.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.3.5397