ABSTRACT

One of the most common cancers prevailing among women is Breast cancer which also is the leading cause of cancer deaths. Enormous strategies have been developed so far to combat and treat breast cancer by improving the methodologies followed for treatment. Still we face various challenges like lack in early detection, side effects of chemotherapy, development of secondary cancer, and drug resistance offered by the cancerous cells. These drawbacks could be overcome better by targeted therapy against the various sub-classes of breast cancer, especially triple-negative breast cancer than the conventional ones. Most recent investigation paid paramount attention on the dysregulation of major signaling pathways that leads to cancer. Wnt signaling pathway has been considered as one of the most crucial passages that ends up in breast cancer. In this review we throw more light on the role played by the Wnt signaling pathway in promoting breast cancer and the various treatments which involve the deliberate targeting of the various molecules associated in the pathway. Key words: Antimicrobial peptides, Wnt signaling pathway, Breast cancer, ?-catenin, chemotherapy
Publication date: 01/03/21

https://ijbpas.com/pdf/2021/March/MS_IJBPAS_2021_5393.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.3.5393