ABSTRACT

Gastro retentive drug delivery systems are one of the most feasible approaches for achieving a prolonged and predictable drug delivery profile in the GI tract to control the gastric residence time. These are primarily controlled release drug delivery systems, which gets retained in the stomach for longer periods of time, thus helping in release of drug for the intended duration of time. The aim of the present study is to formulate, characterize and perform In vitro dissolution studies of gastroretentive floating tablet Venlafaxine HCl. Venlafaxine HCl an anti depressant drug is a BCS class I drug having high solubility and high permeability. The main objective of the study was to prolong the drug release time by increasing the gastric residence time. Various formulations were developed by using varying ratios of Carnauba wax, White paraffin wax, Compritol ATO 888 and Cetyl alcohol as hydrophobic retardants and HPMC K100M as hydrophilic polymer. The FTIR and DSC data indicated that there were no interactions between the drug and polymers used. The tablets were prepared by Hot melt granulation or Thermoplastic granulation method and were evaluated for various parameters such as tablet hardness, weight variation, friability, floating time and In vitro drug release profile. Formulation S6 with hydrophobic polymer white paraffin wax and hydrophilic polymer HPMC K100M in the ratio of 1:3 was the optimized formulation. The optimized formulation showed satisfactory sustained release of drug for about 12 hrs . Keywords: Gastro retentive, Anti-depressant, Melt granulation, Buoyancy
Publication date: 01/03/21

https://ijbpas.com/pdf/2021/March/MS_IJBPAS_2021_5392.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.3.5392