ABSTRACT

Endometriosis is characterised by the presence of endometrial stroma and glands outside of the uterus lining and is thought to affect 10-15% women within the reproductive age often leads to infertility and results in reduced quality of life. Among various theories regarding the pathogenesis of endometriosis oxidative stress is one that may be associated with endometriosis etiology. Oxidative stress is detected when an imbalance between oxidants and prooxidants occurs which further leads to inflammatory response in peritoneal cavity and may have an indispensable role in the pathogenesis of endometriosis. Antioxidant system comprises of different components such as super oxide dismutase, catalase and glutathione peroxidase which has the potential to remove harmful free radicals and inhibit cell’s structural damage. Non-enzymatic antioxidants such as vitamin C and vitamin E play an important role to influence the complex antioxidant defence system of the body. Imbalance between the production of ROS and prooxidants leads to rise in ROS level and further results in oxidative stress that is implicated as key player in endometriosis pathogenesis. Current study analysed the levels of different oxidative stress biomarkers to quantify the severity and development of endometriosis as well as establish diagnostic biomarker for endometriosis. Keywords: Reactive oxygen species (ROS), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and vitamin E (vit E)
Publication date: 01/02/21

https://ijbpas.com/pdf/2021/February/MS_IJBPAS_2021_5390D.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.2.5390D