ABSTRACT

Endometriosis is defined as the presence of endometrium outside of uterine cavity and thought to develop through reverse menstruation of endometrial tissue into the peritoneal cavity. Endometrial cell implantation into peritoneal cavity is a crucial process in the onset of endometriosis. Interestingly during implantation some features of malignancy are demonstrated by endometrial cells, as they have the ability to attach and to invade the peritoneum or ovary structure. This invasion is effectuated with a group of enzymes known as matrix metalloproteinases (MMPs) which may contribute in extracellular matrix (ECM) degradation. ECMs and protein degrading activity of cell surface proteins play a critical role in pathophysiology of endometriosis. During inflammation activated neutrophils, macrophages and eosinophils stimulate the production of MMPs in peritoneal cavity of female with endometriosis. The objective of present study was to access the expression of MMP-2, MMP-7 and MMP-9 in glandular epithelial cells of endometriotic tissue and normal endometrium to elucidate the role of MMPs in the pathogenesis of endometriosis. Keywords: Matrix metalloproteinases (MMPs), Extracellular matrix (ECM), Matrix metalloproteinase-2 (MMP-2), Matrix metalloproteinase-7 (MMP-7), and Matrix metalloproteinase-9 (MMP-9)
Publication date: 01/02/21

https://ijbpas.com/pdf/2021/February/MS_IJBPAS_2021_5390C.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.2.5390C