ABSTRACT

Endometriosis is an inflammatory condition characterised by existence of endometrial tissue in extra uterine locations, being aggressive and invasive can cause a significant decrease in quality of life. Various scientific evidence suggests that peritoneal fluid of women suffering from endometriosis has elevated concentration of proinflammatory cytokines, reactive oxygen species as well as rich in low density lipoprotein which are able to upregulate the formation of oxidised lipid components in an inflammatory milieu along with increased number of active macrophages. Consequently formation of inflammatory response together with the existence of local oxidative environment possibly play an active role in the pathogenesis of endometriosis. It has been reported that lipidperoxidation end products are increased in serum of women with endometriosis. Current study was aimed to identify the levels of lipidperoxidation biomarkers in women diagnosed with advance stage of endometriosis in order to determine the status of lipidperoxidation as well as lipidperoxidation end product induced DNA damage in women with endometriosis. Keywords: 8-hydroxy-2’-Deoxyguanosine (8-OHdG), Malondialdehyde (MDA), 4- Hydroxynonenal (4-HNE), Isoprostanes, reactive oxygen species (ROS)
Publication date: 01/02/21

https://ijbpas.com/pdf/2021/February/MS_IJBPAS_2021_5390B.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.2.5390B