MITOCHONDRIAL-TARGETED DRUG DELIVERY Authors: Ziyu Chen , CAN ZHANG AND ZHIGUI SU
ABSTRACT
Mitochondrion is an important organelle in the cell, playing critical roles in various biological
processes, such as calcium homoeostasis, cellular stress response, cellular metabolism and
cellular apoptosis. Thus, mitochondrion is also a promising therapeutic target for solving
current clinical issues and preventing various human diseases such as diabetes, Alzheimer’s
disease, cardiovascular disorders, and cancer. In this review, firstly, we aimed at the function
and influence of mitochondria in diseases. Furthermore, the targeting strategies to
mitochondrion based on the highly negative potential of mitochondrial membrane and
mitochondrial import proteins were also discussed for developing more efficient treatments
for mitochondrial diseases.
Keywords: Mitochondrion, drug delivery, nanoparticle, cationic ligand Publication date: 01/02/21 https://ijbpas.com/pdf/2021/February/MS_IJBPAS_2021_5370.pdfDownload PDFhttps://doi.org/10.31032/IJBPAS/2021/10.2.5370
