ABSTRACT

Objective: The Aim of the present study is to formulate and evaluate the formulated cross-linked hydrogel containing piperine for the topical wound healing application. Methods: The hydrogel containing piperine hydrogels were prepared by cross-linking method with the different concentrations of xanthan gum. Homogeneity, Rheological Studies, swelling studies, scanning electron microscopy (SEM) and in vitro drug release studies were carried out. Results: The formulated hydrogel containing piperine was evaluated and based on the surface morphology, swelling studies, homogeneity, rheological studies and in vitro drug release studiesthe formulation F4 shows good results when compared to the other formulations. Conclusion: Hydrogel system could play an important role in the treatment of skin injuries and infection. Cross-linked polymeric hydrogel membranes loaded with the piperine were synthesized successfully with an optimized process of cross linking which would act as new healing system for the wound healing burns with controlled release manner at wound site by preventing infection and increased healing efficiency through a contact. Key words: SEM, Piperine, Hydrogel
Publication date: 01/02/21

https://ijbpas.com/pdf/2021/February/MS_IJBPAS_2021_5345.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.2.5345