ABSTRACT

The present study explores the antimicrobial potential of Callistemon lanceolatus leaves. Different extracts of Callistemon lanceolatus leaves revealed its broad-spectrum antimicrobial potential where Staphylococcus aureus and Klebsiella pneumoniae 1 were the most sensitive. Cardiac glycosides were most abundant and showed maximum antimicrobial activity closely followed by phytosterols. Both ethyl acetate extract and phytoconstituents showed lower minimum inhibitory concentration as compared to gentamicin and were microbicidal in nature. The results of antimicrobial screening, minimum inhibitory concentration, viable cell count and post antibiotic effect corroborated well with each other. Antiproliferative attribute of C. lanceolatus ethyl acetate extract and phytoconstituents against MCF 7 cell line is being reported for the first time and were found to be biosafe as revealed by Ames and 3-(4,5-Dimethylthiazol- 2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay. The current exploration of C. lanceolatus leaves holds a promising antimicrobial as well as anticancer attribute of the plant extract as well as its phytoconstituents. The biosafe nature of the above also adds importance to the study to be taken up further. Keywords: Antimicrobial, Callistemon, Phytoconstituents, Antiproliferative, Biosafety
Publication date: 01/02/21

https://ijbpas.com/pdf/2021/February/MS_IJBPAS_2021_5340.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.2.5340