ABSTRACT

Neurodegenerative diseases became an encumbrance to the society, especially the geriatrics. Various plants are available in the literature having the protective, memory and cognitive enhancing properties. The current work has been taken to approach it through two of them. The study was aimed to screen the phytochemical, acute toxicity studies, nootropic activities (In vivo) of ethanolic extract of Lepidium sativum (LS) and Trigonella foecum (TF) and also to develop a solid dosage form using the combined ratio extracts (1: 1) with suitable excipients to get the synergistic/ complementary effects. Preliminary phytochemical investigation, acute toxicity study was evaluated and the therapeutic dose was fixed for the combined test ethanolic extracts. Combination (1:1) of extracts of ESLS and ESTF were screened for the effect on memory and cognition on mice both by discrimination learning and avoidance behaviour. The herbal tablets were formulated using the direct compression method and evaluated for pre and post compressional parameters. The results for the various maze experiments showed statistically significant (p<0.05) improvement in both working and spatial memory in animals. The extract blend was formulated as tablets using suitable excipients are found to be within the range. From the results, it was found that the extracts are safe even at high doses (2000mg/kg body weight) and the behavioural studies results affirmed the nootropic effects of the extract combined mixture of ESLS and ESTF at a dose of 200 and 400mg/kg body weight. Keywords: Nootropic, cognitive, memory, formulation, evaluation
Publication date: 01/07/20

https://ijbpas.com/pdf/2020/July/MS_IJBPAS_2020_51011.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.7.5101