ABSTRACT

Saccharum officinarum Linn (Poaceae) a persistent, juicy plant was evaluated for its neuroprotective effects in various animal models i.e. Compulsive behaviour (stereotypy), CNS Depressant Activity (Locomotor activity) and Forced swim test. Administration of fresh juice of Saccharum officinarum Linn, showed an increase in exploratory functions as compared to the control group in a dose dependant manner. Fresh juice of Saccharum officinarum Linn, significantly (p < 0.01) increase in CNS depressant activity of the animals in locomotor activity. A significant (p<0.01) dose-dependent antidepressant effect was observed in forced swim test. A dose dependent compulsive behaviour property was observed. Phytochemical screening of fresh juice of Saccharum officinarum Linn, revealed the presence of alkaloids, glycosides, steroids, saponin, tannins, proteins, phenolic compounds and flavonoids. A number of researcher reported that the alkaloids, glycosides, and flavonoids rich plant fresh juice possess neurological and compulsive behavior properties properties mediated, through their affinity with benzodiazepine site of GABAergic complex system in the brain producing drowsiness and facilitating or maintaining sleep. The results obtained in this study suggest that the fresh juice of S. officinarum L. possesses Neurological and Compulsive behavior properties. Thus, S. officinarum L. has potential clinical applications in the management of anxiety and muscle tension disorders. Further investigations are warranted for elucidating the exact mechanism and bioactive compounds. Keywords: Neurological and Compulsive behavior properties, Saccharum officinarum L., Diazepam, Rearing
Publication date: 1/1/21

https://ijbpas.com/pdf/2021/January/MS_IJBPAS_2021_5358.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.1.5358