ABSTRACT

Carissa carandas (Apocynaceae) is a species of flowering shrub. The plant bears a berry- sized fruits which is commonly used as a condiment and additive to pickles and spices. The fruits, leaves, barks, and roots of Carissa carandas have been used for ethnopharmacologically. Chemical constituents mainly reported are steroids, terpenes, tannins, flavonoid, benzenoids, phenylpropanoid, lignans, sesquiterpenes, and coumarins. Carissa carandas has been shown to have anticonvulsant effects via non-specific mechanisms since it reduced the duration of seizures produced by maximal electroshock as well as delayed the latency of seizures produced by pentylenetetrazole and picrotoxin induced seizures. In the present study ethanolic extracts of fruit of Carissa carandas was screened for various hematological and biochemical effects with the hope of finding safe and effective natural medicines. The effect of Carissa carandas extract on biochemical parameters (Blood glucose, AST, ALT, Urea, Creatinin and bilurubin) showed that the plant did not affect most of these parameters except the ALT and Urea levels. The different doses of ethanolic extract of Carissa carandas produced a significant reduction in ALT level in a dose dependent manner. Administration of etahnolic fruit extract extracts of Carissa carandas, showed no sign of toxicity in experimental animals and can be used safely. Keywords: Carissa carandas, Biochemical, Hematological, Toxicity
Publication date: 1/1/21

https://ijbpas.com/pdf/2021/January/MS_IJBPAS_2021_5335.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.1.5335