ABSTRACT

Human liver cell line is considered the most suitable toxicology as well pharmaceutical experiments for drugs development. HepG2 cells and primary hepatocytes have proven useful in in-vitro studies. HepG2 cells as liver cells are used in this study, some azoles have proliferative capability on liver cells proliferation activity of different azoles observed in this study. This study has shown proliferation activity of fluconazole, omeprazole, voriconazole and itraconazole out of all itraconazole showed more proliferation of liver cells compared with untreated cells as well rest of three treated group estimated via MTT and antioxidants also act as antiapoptotic agents to reduce apoptosiswith antioxidant after treatment cells showed enhanced oxidative level proliferation was estimated via VEGF ELISA and apoptosis via p53 ELISA. Keywords: Liver cell line, azoles (fluconazole, omeprazole, voriconazole and itraconazole), angiogenesis, anti-apoptosis and proliferation
Publication date: 1/1/21

https://ijbpas.com/pdf/2021/January/MS_IJBPAS_2021_5319.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.1.5319