ABSTRACT

Benzydamine hydrochloride is a non-steroidal drug which has analgesic, anesthetic, antiinflammatory, antipyretic and anti-microbial properties. Although many pharmacological effects of benzydamine have been established, the exact mechanism of action of benzydamine hydrochloride is yet unknown. The aim of this study is to evaluate the topical analgesic and anesthetic efficacy of 0.15% benzydamine hydrochloride mouthwash with placebo in noninflamed mucosa. This study involved 20 volunteers with healthy gingiva who were subjected to two sessions of drug application at an interval of 3 days. The subjects were topically treated with test drug (0.15% benzydamine hydrochloride mouthwash) or placebo in a random manner. At each session, after a total of 3 minutes from drug application, a 26-gauge needle was injected into the test site to a depth of 2-3mm. During and immediately after the needle insertion, each participant quantified the pain perceived using a 10-point visual analog scale (VAS). Analysis with t-test showed that there was a significant difference between the pain scores with 0.15% benzydamine hydrochloride mouth rinse and normal saline mouth rinse (P < 0.05). In conclusion 0.15% Benzydamine hydrochloride Mouthwash produces significant topical analgesia and anesthesia even in non-inflamed mucosa. Keywords: Benzydamine, Anesthesia, Topical analgesia, Pain, Visual analog scale
Publication date: 1/1/21

https://ijbpas.com/pdf/2021/January/MS_IJBPAS_2021_5310.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.1.5310