Depression is potentially life-threatening disorder which is affecting people worldwide. It is
not limited by age and is a curse to the society as it causes severe distress and, if left
untreated, can even cause death. There are different chemical moieties showing
antidepressant properties such as benzodiazepines, hydrazones, imidazoles, indoles,
piperazines, piperidines, pyrazolines, pyrimidines, pyrrolidones, quinazolines, quinolines, thiadiazoles and triazoles. Among all these chemical moieties, the pyrazolines possess a
broad spectrum of pharmacological activities such as analgesic, anti-pyretic, antiinflammatory,
insecticide, uricosuric, anti-epileptic, anti-depressant, anti-microbial, anticancer,
anti-tubercular, hypotensive, anti-nociceptive, and anti-oxidant activity. Recently
synthesized antidepressants having pyrazoline moiety has been the highlight of this present
review. It has been found that most of the substitutions are taking place in the 1st, 2nd, 3rdand
5th position to exhibit antidepressant property in the form of MAO inhibition. The substitution
in the 4th position has found to decrease the activity, but fused phenyl ring in the 3rd and 4th
position exhibited acute potency. Marked response is observed when 3rd and 5th positions
encounter substitutes or non substituted six membered aromatic rings attachment along with
substituted thioacetamide in the 1st position. These conclusions were drawn on the basis of
results obtained from Despair Swim Test.
Keywords: Pyrazolines, Antidepressant property, MAO inhibition
Publication date: 1/1/21
https://ijbpas.com/pdf/2021/January/MS_IJBPAS_2021_5305.pdf
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https://doi.org/10.31032/IJBPAS/2021/10.1.5305
