ABSTRACT

Marine microbes are rich sources for various types of bioactive compounds. In the present study, the effective antagonistic bacterial strain KA2 was isolated from soil samples collected from the coastal region of Karaikal seashore. The isolated bacterial strain was genomically identified as Pseudomonas sp. The crude secondary metabolite extract (CSME) from the strain was extracted using ethanol and examined for its chemical composition. Further, the CSME was analyzed for their antibacterial and antioxidant activity. The anticancer activity of CSME of KA2 against human oral squamous carcinoma KB cell line was analyzed by MTT assay. The results showed that the CSME of KA2 exhibited effective antimicrobial activity against selected gram-positive and gram-negative bacterial pathogens. Further, showed effective DPPH radical scavenging activity in concentration established way. Moreover, the CSME of KA2 exhibited effective anticancer activity against both tested cancer cell lines with the IC50 value of 101.49±2.15 ?g/mL. Therefore, the secondary metabolites of strain Pseudomonas sp KA2 could be used for effective antibacterial and anticancer treatment after the proper clinical and pharmacological trial. Keywords: Pseudomonas sp, Gram-positive, Anticancer, Oral cancer
Publication date: 1/12/20

https://ijbpas.com/pdf/2020/December/MS_IJBPAS_2020_5644.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2020/9.12.5644