SYSTEMATIC SCREENING FOR ANTICANCER ACTIVITY OF ANTIMICROBIAL PEPTIDES Authors: Kanitha S And Malarvili T*
ABSTRACT
Cancer has become one of the predominant causes of elevated death rate globally. In spite of
exhaustive research in devising new therapeutic approaches for treating cancer, regrettably the
discomfort and the difficulties still persists. The unfocused action of anticancer drugs and the drug
resistance developed by the cancer cells, prevail as the two most vital drawbacks of the current therapy.
For this reason there is a frantic need for the optional targeted therapeutic approaches. Presently the
Antimicrobial Peptides have come under the lime lights as anticancer agents. In our present study we
collected antimicrobial peptides from various repositories. As the length of the peptide decides its
anticancer property, we then selected 40 antimicrobial peptides with 5-30 amino acid residues. Those
peptides were then thoroughly studied for their physico-chemical properties, following which 15 peptides
with greater positive charge were selected. Further the 15 peptides were analysed for their amino acid
composition and finally for our further studies we chose 6 best peptides namely NSAAACP001,
NSAAACP002, NSAAACP003, NSAAACP004, NSAAACP005 and NSAAACP006. AntiCP and
ToxinPred web portals were then made use of to confirm the anticancer property and toxic activity of the
selected 6 peptides respectively and all the peptides were observed to be anti-cancerous and non-toxic in
nature.
Key words: Cancer, Antimicrobial peptides, Anticancer peptides, Targeted therapy, AntiCP, ToxinPred Publication date: 01/12/2020 https://ijbpas.com/pdf/2020/December/MS_IJBPAS_2020_5581.pdfDownload PDFhttps://doi.org/10.31032/IJBPAS/2020/9.12.5581
