ABSTRACT

Oxidative stress mediated injury is one of the major reasons of occurrence of neurodegeneration which leads to Parkinson’s disease and Alzeimer’s disease. Alpha-lipoic acid (ALA) is a vitaminlike chemical and a potent antioxidant with the potential use as medicine. Till now there are no reports with ALA for the neuroprotective action with rotenone (ROT) challenge by using Zebra fish, so this work has been done to explore the neuroprotective activity. Adult male Zebra fish (n= 12) were used and simultaneously exposed allowed to swim to ROT 50?g/ml and ALA 500?g/ml in a glass water tank of 2L for 14 days, and the methods like biochemical parameters from brain tissue, behavioral studies and histopathology studies were done to prove neuroprtection. ROT produced marked decrease in the Zebra fish swimming behavior and induced the locomotor and cognitive impairment significantly. ROT +ALA combined treatment significantly improved the swimming behavior and attenuated the locomotor, cognitive impairments induced by ROT. The results were confirmed by the histopathological findings also. The results concludes that the ALA was effective against the toxicity induced by ROT in Zebra fish as well as confirms the significance of this model to explore possible therapeutic approaches with ALA on cognitive impairments and movement disorders and further studies are needed to explore the therapeutic use of ALA in Parkinson’s and Alzheimer’s diseases. Key words: Alpha-lipoic acid, Zebra fish, Rotenone, Neurodegenerative disorders
Publication date: 01/12/2020

https://ijbpas.com/pdf/2020/December/MS_IJBPAS_2020_5271.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.12.5271