Neurodegeneration refers to a condition of neuronal death occurring as a result of progressive
disease of long-term and is becoming a major health problem in the 21st century. Neurons
degenerated are not replaced resulting in a cognitive loss, many neurodegenerative disorders,
such as schizophrenia, depression, Alzheimer's disease (AD), dementia, cerebrovascular
impairment, seizure disorders, head injury, parkinsonism. The common pathology of
neurodegeneration includes deposition of misfolded proteins such as amyloid-? (A?) in
Alzheimer’s disease, ?-synuclein in Parkinson's disease (PD), transactive response DNAbinding
protein 43 (TDP-43) in dementia. Neuroprotection refers to the strategies and
possible mechanisms that are able to protect the central nervous system (CNS) against
neuronal injury and neurodegenerative disorders. The past decade has witnessed an intense
interest in herbal plants having long-term health-promoting or medicinal qualities.
Comprehensive research and discovery have demonstrated that natural products, medicinal
herbs, plant extracts, and their metabolites, have great potential as the neuroprotective agent.
Although the precise mechanisms of action of herbal drugs have yet to be determined, some
of them have been shown to prevent formation of beta-amyloid plaques, promote nerve
growth, some inhibit acetylcholinesterase (AChE) enzyme and malondialdehyde (MDA)
formation in brain while other exhibits antioxidant activity by increasing the level of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx). Thus the herbal
plants can be a valuable source of the drug against neurodegenerative disorders which will
require high-throughput screening. This review will highlight the role of herbal plants and
their phytoconstituents against neurodegenerative diseases and other related disorders,
focusing on their mechanism of action and therapeutic potential.
Keywords: Alzheimer’s disease, Amyloid-?, Antioxidant, Dementia, Herbal medicine, Neurodegenerative diseases, Neuroprotective
Publication date: 01/12/2020
https://ijbpas.com/pdf/2020/December/MS_IJBPAS_2020_5258.pdf
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https://doi.org/10.31032/IJBPAS/2020/9.12.5258
