ABSTRACT

Breast cancer is the most commonly occurring cancer in women and the second most common cancer overall. Metastases are major cause for the Breast cancer associated deaths. Epithelial-to- Mesenchymal Transitions (EMT) attune the micro environment of tumors and are recognized in the progression of metastatic disease. This propagation of tumor cells from the primary site is the foremost challenge in cancer treatment as they are resistance to conservative therapies. Thus, investigation of effective drug targets against these cancer cells is necessary. The potential of Dioscin, a natural steroidal saponin on EMT induced MCF7 and MDA-MB-231 cells has not been explored. In the present study, we performed to elucidate the effectof Dioscin in modulating metastatic related behaviors of breast cancer cells. Transforming growth factor beta 1 (TGF-?1) is used to induce EMT and promote breast cancer cell migration and invasion in vitro. Dioscin inhibited TGF-?1 induced cell migration and invasion in MCF7 and MDA-MB-231 cells. Also, Dioscin significantly increased the expression of E-Cadherin and decreased the expression of N-Cadherin and Vimentin. Based on these results, Dioscin may be considered as a promising compound for the treatment of advanced Breast cancer cells. Keywords: Breast cancer, Metastasis, Dioscin, Epithelial-to-Mesenchymal Transitions (EMT) and TGF-?1
Publication date: 01/11/2020

https://ijbpas.com/pdf/2020/November/MS_IJBPAS_2020_5487.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.11.5387