ABSTRACT

The growth of antibiotic-resistant microbes is increasing at an alarming rate and hence its creating difficulties in the treatment of various infectious diseases and hence there is an urgent need for new and efficient antimicrobial agents that could help to combat the problem easily. The plant-derived compounds have shown to act as the potential compounds that have good antimicrobial compounds as well as they can modify the activity of standard drugs when administered in combinations. In the present study, the methanolic extract was prepared for both the selected plants that are Tinospora cordifolia and Eclipta prostrata, the methanolic extracts were then analyzed for the presence of potentially bioactive compounds followed by the determination of their antimicrobial property against K. pneumoniae, P. aeruginosa and S. aureus. Then the synergistic property of the extracts with four different antibiotics was determined by obtaining the MIC value for their individual and combined effects. The MIC value was used for the calculation of Fractional inhibitory concentration (FIC) followed by the calculation of fractional inhibitory concentration index (FICI) value that helped to interpret the type of interaction possessed by the plant extract and antibiotic combinations. The results obtained from the study clearly depicted that both the plant extracts have shown to be a potential antibacterial agent as they are rich in bioactive constituents. The FICI value has shown that the better and maximum synergistic property has been shown by the methanolic extract of T. cordifolia while the methanolic extract of E. prostrata also showed it for some combinations. The study concludes that these plants could be considered for the formulations of new antimicrobial drugs that could impart a better and effective activity against the Multi-drug resistance pathogenic microbes. Keywords: Bioactive compounds, Pathogenic bacteria, Antimicrobial property, Synergistic activity
Publication date: 01/11/2020

https://ijbpas.com/pdf/2020/November/MS_IJBPAS_2020_5351.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.11.5351