ABSTRACT

Oral Lichen Planus (OLP) is a chronic inflammatory autoimmune mucocutaneous disease characterized by a T cell-mediated immune response against epithelial cells. Diagnosis and treatment of these lesions is always challenging. Prior to the start of treatment, disease activity or severity should be scored which will determine the disease prognosis, response to treatment. This study aims to validate the oral disease severity scoring (ODSS) developed by Guy's Hospital for Oral Lichen Planus. 10 adult patients between 30 – 65 years, newly diagnosed with erosive lichen planus (based on clinical and histopathological findings) participated in the study.Pre - treatment ODSS was done to assess oral involvement.Post - treatment oral disease scoring was done after 4 week of topical steroid therapy.10 patients (2 males/ 8 females) with clinically proven erosive Lichen planus were included in the study.The pre- treatment mean oral disease severity score was 29.1 ± 12.235 and 4 weeks post treatment - 19 ± 6.325. The overall improvement in severity was 53%.Scoring disease activity and severity would give a quantification to assess the disease process.Response to treatment and disease status during each follow - up can be assessed.Routine use of validated disease severity score would be an ideal tool for multi - centric research and drug trials. Keywords: oral lichen planus, disease severity, mucocutaneous diseases
Publication date: 01/11/2020

https://ijbpas.com/pdf/2020/November/MS_IJBPAS_2020_5291.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.11.5291