ABSTRACT

The compatibility studies are an important phase that should be performed at the preformulation stage. The physical and chemical interaction between the drug and excipients can affect the chemical nature, stability, bioavailability, the therapeutic efficacy and safety of a drug and its dosage form. The compatibility studies of drug Lisinopril with different excipients were performed using the analytical techniques like Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Isothermal Stress Testing (IST) and High-Performance Liquid Chromatography (HPLC). The compatibility study of Lisinopril was performed with PVPk30 polymer, Polyplasdone XL, Indacol allurared, 1:1% mixture the drug, each excipient was prepared and stored at 40°C real humidity for one month. The studies were compared to find out the drug interaction between drug and excipients mixture was examined, no interaction with the results of Lisinopril and selected excipients, it indicates no concrete evidence of interaction between drug and the excipients. The finding results have shown that the selected excipients were found to be compatible with the drug, it can be used for the oral disintegrating film formulation. Keywords: Lisinopril, compatibility, DSC, FTIR, IST, HPLC, Oral disintegrating films
Publication date: 01/10/2020

https://ijbpas.com/pdf/2020/October/MS_IJBPAS_2020_5428.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.10.5428