ABSTRACT

Background: Onychomycosis is a chronic fungal infection of nail units. It is not only caused by dermatophytes. It also caused by yeasts and non-dermatophyte molds. Aim: To compare the effectiveness of oral terbinafine and oral itraconazole used in the Management of onychomycosis using onychomycosis severity index (OSI) scoring. Materials and method: A prospective observational study was conducted in the department of dermatology, venereology and leprosy (DVL) at Rajah Muthiah Medical College & Hospital (RMMCH) over a period of six months from November 2018 to April 2019. The data was collected from 50 patients using a specially designed data collection form. Patients were selected based on inclusion and exclusion criteria. Results and discussion: A total of 50 patients were included in this study. They were separated into two treatment Groups (A and B), each group had 25 patients. In group A patients receiving terbinafine and in group B patients receiving itraconazole as a treatment. Among these patients, males (66%) were more affected than females (34%). Before starting treatment, in group A 52% of patients had severe onychomycosis, whereas 32% and 16% were affected with mild to moderate onychomycosis. In group B 40% of patients had severe onychomycosis, whereas 36% and 24% were affected with mild to moderate onychomycosis. After treatment, in group A 76% were cured and 24% were the mild stage, and in group B, 64% were cured and 36% were in mild stages. Conclusion: This study concludes that terbinafine is more effective than itraconazole in the management of onychomycosis. Keywords: Onychomycosis, Terbinafine, Itraconazole, onychomycosis severity index
Publication date: 01/10/2020

https://ijbpas.com/pdf/2020/October/MS_IJBPAS_2020_5253.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.10.5253