ABSTRACT

The aim of this systematic review was to evaluate the role of microRNA-31 in saliva, serum and tissue as a diagnostic marker in Oral Potentially Malignant Disorders and Oral Cancer. In this study the existing literature has been evaluated to check if microRNA-31 from saliva, serum and tissue serves as an early diagnostic marker in Oral Potentially Malignant Disorders and Oral Cancer to analyse the up regulation and downregulation of microRNA-31 in oral potentially malignant disorders. Studies have shown that the tissue expression of microRNA-31 was seen in an early event of leukoplakia turning into malignancy. Expression of microRNA-31 has been found to be disregulated in almost all types of cancers. microRNA-31 mainly targets the tumor suppressor genes and affects the process of carcinogenesis. The identification of microRNA-31 in saliva,serum and tissue samples in Oral Potentially Malignant Disorders and Oral Cancer can thus serve as an early diagnostic marker before it progresses to carcinoma. Keywords: Lichen Planus, microRNA, Oral Potentially Malignant Disorder, Oral Cancer, Oral Submucous Fibrosis
Publication date: 01/10/2020

https://ijbpas.com/pdf/2020/October/MS_IJBPAS_2020_5226.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.10.5226