ABSTRACT

Various species of the genus Ipomoea are mostly used in traditional medicine. Ipomoea horsfolliae Hook were selected because there is nosystematic toxicity studies for this plant were described. So the present study was undertaken to assess acute and sub-acute toxicity of this plant in mice and rats. The acute oral toxicity study were carried out as per the OECD guidelines 425 in mice and the sub-acute toxicity were carried out at as per OECD guidelines 407 in male and female rats. Mice administered up to 2000 mg/kg as a single dose orally not caused any signs of toxicity or mortality in mice. In sub-acute toxicity study in rats, ethyl acetate extract of Ipomoea horsfolliae Hook (EAIH) at three different daily doses of 150, 300 and 600 mg/kg for 28 days did not cause any significant change including the hematological and biochemical parameters. Histopathological examinations showed normal architecture suggesting no morphological disturbances. No deaths or any signs of toxicity was observed after oral administration in acute and toxicity studies according to OECD guidelines concluded that EAIH can use for in vivo biological activity studies in laboratory animals to explore its various medicinal activity prior to study in human subjects. Keywords: Ipomoea horsfolliae Hook; mice; acute toxicity; sub-acute toxicity; rats
Publication date: 01/10/2020

https://ijbpas.com/pdf/2020/October/MS_IJBPAS_2020_5204.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.10.5204