ABSTRACT

Aluminium is one of the major environmental neurotoxin, whose exposure produces several adverse effects. The severity of damage depends on the time and levels of exposure, the rate of absorption, individual susceptibility and the route by which the metal is absorbed. Aluminium has been reported that it can lead to Alzheimer's disease despite the controversy around the issue. When aluminum is absorbed into your brain, it lasts over a very long period and the half-life is reported to be 20% of lifetime. Although the precise cause of aluminium toxicity is unclear, the studies indicate that aluminium can enhance the inflammatory and oxidative events resulting in the synthesis of reactive oxygen- species and the degradation of antioxidant defense enzymes, which contribute to increased mitochondrial oxidative stress. This review attempts to describe the causes of exposure, symptoms of toxicity and molecular mechanisms by which neurotoxins can cause neurotoxicity, prevention and treatment for the aluminium induced neurotoxicity. Keywords: Neurotoxin, Aluminium Neurotoxicity, Mechanisms, Symptoms, Prevention and Treatment, Neuroprotective Agents
Publication date: 01/10/2020

https://ijbpas.com/pdf/2020/October/MS_IJBPAS_2020_5203.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.10.5203