Aim & Objective: Evaluation Of Anti-hyperlipidemic Activity of Saccharum Officinarum L
Plant fresh juice.
Material and Methods: This was a laboratory based experimental study. A total of 24 Wistar
Albino rats were divided into four groups as the control group (1.5 mL distilled water), the PCM
group (3000 mg/kg PCM), Clofibrate + PCM group (50mg/kg + 3000 mg/kg PCM), the S.
Officinarum L. juice + PCM group (1.5 mL S. Officinarum L. juice + 3000 mg/kg PCM) and
Saccharum Officinarum L. juice and distilled water were administered for eight days.
Paracetamol was administered on day 8th. The level of thiobarbituric acid reactive substances, as
an oxidative marker, was measured in the blood and liver tissue on day 9th. In addition, liver
tissues were evaluated histological (in terms of increased vein inlet, connective tissue, granular
degeneration, mononuclear cell infiltration, necrotic cells and vascular congestion).
Results: In hyperlipidemic control group paracetamol 3000mg/kg resulted in a significant
increase in TG, TC, LDL, VLDL, atherogenic index and a significant decrease was found for
HDL values compared with normal control. The treatment group of Clofibrate (50 mg/kg) and
Saccharum Officinarum L juice (1.5ml, p.o.) showed significant decrease in TG, TC, LDL,
VLDL, atherogenic index and serum glucose compared with hyperlipidemic control.
Conlusion: The study revealed that Clofibrate, Saccharum Officinarum L juice (1.5ml, p.o.) possesses significant Antihyperlipidemic activity. Among all treated group dose of Saccharum
Officinarum L juice found to be more effective against paracetamol 3gm induced
hyperlipidemia.
Keywords: Antihyperlipidemic effect, Saccharum Officinarum L, Hyperlipidemia, Paracetamol,
Albino rats
Publication date: 01/10/2020
https://ijbpas.com/pdf/2020/October/MS_IJBPAS_2020_5201.pdf
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https://doi.org/10.31032/IJBPAS/2020/9.10.5201
