ABSTRACT

The durian fruit Durio zibethinus as an important source of phenolic compounds, that phenolic compound is a good natural resource of induced apoptotic properties. Hence, the present study was planned to predict the molecular interaction between the GC-MS spectral volatile compounds from Durio zibethinus (ethyl (2S)-2-methylbutanoate and 1- (ethylsulfanyl) ethane-1-thiol) with apoptotic proteins (Caspase-3, Caspase-9, Bax, Bcl-2 and Bcl-xl) by ARGUSLAB docking software. The result of Lipinski rule suggests that compounds as best therapeutic drug for cancer. Docking study and in silico toxicity results proves the application of compounds as potential and natural therapeutic agents to treat disease. Keywords: Durian, GC-MS, Molecular Docking, ARGUSLAB and Apoptotic Proteins
Publication date: 01/09/2020

https://ijbpas.com/pdf/2020/September/MS_IJBPAS_2021_5372.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.9.5372