ABSTRACT

The current study is focus to choose the best suitable method for preparation of Clarithromycin & Cefuroxime Axetil encapsulated Nasal Mucoadhesive microspheres by Analytical hierarchical analysis (AHP) with utilizing the multi-criteria decision making model. The Appropriate approaches of formulation using simple and effective method are revolutionizing the adoptive techniques in technology transfer in manufacture of pharmaceuticals. Mostly AHP has been utilised in almost all disciplinary areas related to decision-making problems. A four level hierarchy model was constructed with four methods of microsphere preparation methods like Spray Drying, Solvent Evaporation, Ionic Gelation and Emulsion Solvent Evaporation Lyophilisation Method as alternatives. Input Specification Related, Instrument Related, Process Related and Out Put Specification Related parameters were chosen criteria with sixteensub-criteria in this AHP model to obtain overall priority weight and ranking for the selection of suitable method using Pair-wise comparison analysis. The Emulsion – Solvent Evaporation- Lyophilisation Method has the highest value (0.92101) among the alternative method of preparations of Microspheres with order of Spray Drying method (A-2) with a value of 0.692446704, solvent evaporation Method (M-3) with a lowest value of 0.599880707. The highest priority alternative value was considered to achieve the goal, i.e., the best suitable method of preparation for Nasal Mucoadhesive Microspheres. The alternative Emulsion – Solvent Evaporation- Lyophilisation Method score 0.92101 to be chosen among other alternatives and thereby judged to be the most appropriate procedure of preparing Nasal Mucoadhesive Microspheres. Keywords: Analytical hierarchical analysis, Multi Decision criteria analysis, Nasal Microspheres, priority weights
Publication date: 01/09/2020

https://ijbpas.com/pdf/2020/September/MS_IJBPAS_2020_5206.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.9.5206