ABSTRACT

Most popular and convenient route of drug delivery is oral dosage form. But modified release formulations are being developed for better patient compliance and also improving clinical efficacy of the drug. Recent years have seen the use of interpenetrating polymer network (IPN) gain importance in controlled drug delivery. So for our work we have synthesized carboxy methyl derivatives of gum karaya and locust bean gum and also prepared and evaluated IPN hydrogel using the same. For enhancement of this same work we have examined sustained oral delivery potential of carvedilol in vivo. The percentage yield, drug entrapment efficiency, particle size measurement, FE-SEM analysis, drug polymer interaction, DSC, XRD, in vitro release study, swelling study and mucoadhesion study were done to determine the characteristics of the IPN hydrogel beads were done. In vivo hypotensive activity of pure drug suspension and drug loaded IPN hydrogel beads in mice were established. The study revealed the exact combination in which the IPN hydrogel beads were able to entrap almost 100% drug and provide sustained release of carvedilol over a period of 8 hours in simulated intestinal fluid (pH 6.8). The in vivo study in animal model suggested that the IPN formulation could reduce the blood pressure for a much longer duration than with the pure drug suspension. Keywords: Interpenetrating polymer network (IPN), drug, hydrogel, controlled drug delivery, in-vivo, FE-SEM analysis, DSC, XRD
Publication date: 01/09/2020

https://ijbpas.com/pdf/2020/September/MS_IJBPAS_2020_5195.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.9.5195