ABSTRACT

Diabetes is a disorder which requires continuous use of drugs for its maintenance and this disease is characterized by defective insulin secretion and increased insulin resistance. Metformin has a plasma elimination half-life of 3 hours and Glimepiride has 5 hours; therefore, transdermal combination sustained release dosage form was developed by using different plasticizer like Cellulose acetate butyrate (CAB) and Cellulose acetate propionate (CAP), Ethyl cellulose (EC), Dibutyl phthalate (DBP), Dichloromethane (DCM) and Dimethylsulfoxide as penetration enhancer.In vitro studies of all the patches showed expected release for 14 hrs for releasing glimepiride and metformin single dose at faster rate. Among all patches F4 had faster release of 99 98% within 14 hrs. Kinetics of drug release also were showings that F4 formulation that contains combination of polymers EC+CAB follows the Higuchi model which shows the controlled release of drug and confirmed by the Korsmeyerpeppas model of kinetic release. F3 follow the zero order kinetic that implies the drug level in the blood remains constant throughout the delivery. Key words: Metformin Hydrochloride, Glimepiride, Higuchi model, Korsmeyer-peppas model, kinetic model, IR
Publication date: 01/09/2020

https://ijbpas.com/pdf/2020/September/MS_IJBPAS_2020_5193.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.9.5193