ABSTRACT

From ancient times, plants as drugs have been used for different type of disease and disorder or any illness. Raw plant or its formulations were used in different medicinal systems. The phytoconsitituents present in the plants play imperative role in the treatment. Plants extract and formulations supposed to be having few or no side effects. About 800 plants may possess antidiabetic potential. Diabetes is an epidemic disorder spread worldwide. It is estimated that number of patient increase day by day globally. By 2025 it may be cross the number 300 million as per WHO. Currently used drugs for the treatment of diabetes causes several adverse effects. It is the time of challenge and opportunity for the scientist to develop such drugs that has minimum side effects with max efficacy. So the further advance in the development of new drugs becomes the need of future. Now a day’s many scientific approaches like molecular docking utilise in the development drug discovery field. It is an emerging tool now days. This technique utilizes some scoring function for the prediction of binding affinity between two molecules. Phytoconstituents studied with different type of programme for their affinity for particular target/ protein provides great knowledge about the efficacy of molecule. In the present review it is concluded that querecetin, Sitosterol, Stigmasterol, Catechin hydrate, Epigallocatechin, Rutin, Betulin and lupeol shows good binding affinity towards ?-Amylase and ?-Glucosidase. Keywords; Diabetes, Medicinal Plants, Docking Studies, Phytoconstituents, antidaibetic
Publication date: 01/09/2020

https://ijbpas.com/pdf/2020/September/MS_IJBPAS_2020_5185.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.9.5185